タイトル | Effects of Exposure to Microgravity on Neuromuscular Systems: A Review |
DOI | info:doi/10.15011/jasma.31.2.66 |
著者(日) | 永友, 文子; 寺田, 昌弘; 石岡, 憲昭; 石原, 昭彦 |
著者(英) | Nagatomo, Fumiko; Terada, Masahiro; Ishioka, Noriaki; Ishihara, Akihiko |
著者所属(日) | 京都大学; 東京慈恵会医科大学; 宇宙航空研究開発機構宇宙科学研究所学際科学研究系(JAXA)(ISAS); 京都大学 |
著者所属(英) | Kyoto University; The Jikei University School of Medicine; Department of Interdisciplinary Space Science, Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)(ISAS); Kyoto University |
発行日 | 2014 |
発行機関など | 日本マイクログラビティ応用学会 Japan Society of Microgravity Application |
刊行物名 | International Journal of Microgravity Science and Application (IJMSA) |
巻 | 31 |
号 | 2 |
開始ページ | 66 |
終了ページ | 71 |
刊行年月日 | 2014 |
言語 | eng |
抄録 | Parabolic flight lasting 20-30 s and short-term exposure to microgravity for several weeks have been used to examine changes in the neuromuscular system. Previous studies have shown that short-term exposure to microgravity induces an atrophy of fibers, shifting of fiber type from slow-twitch to fast-twitch with synthesis of new fiber types, decreased oxidative enzyme activity, and down-regulation of the mRNA expression of heat shock proteins in the antigravity skeletal muscles of rats. These changes are similar to those observed after decreased muscular activity and loading levels on Earth. Recent studies using long-term exposure to microgravity for several months have also revealed a decreased oxidative capacity of gamma and alpha motoneurons in the spinal cord of mice, as well as degenerative changes in the skeletal muscles. In this article, we reviewed changes in the neuromuscular system in response to parabolic flight of an airplane and short- and long-term exposures to microgravity on orbit around Earth. We especially focused on the oxidative capacity of spinal motoneurons that innervate muscle fibers. |
内容記述 | 形態: 図版あり Physical characteristics: Original contains illustrations |
キーワード | microgravity; neuromuscular system; oxidative capacity; parabolic flight; skeletal muscle fiber; spinal motoneuron |
資料種別 | Journal Article |
NASA分類 | Life Sciences (General) |
ISSN | 0915-3616 |
NCID | AN10537663 |
SHI-NO | AA1440101000 |
URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/15386 |