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64113063.pdf148.67 kB
title培養アストロサイトにおける低線量放射線応答タンパクの解析
Other TitleLow dose radiation-responsive proteins in cultured astrocytes
Author(jpn)三浦, ゆり; 加納, まゆみ; 鈴木, 捷三; 戸田, 年総
Author(eng)Miura, Yuri; Kano, Mayumi; Suzuki, Shozo; Toda, Tosifusa
Author Affiliation(jpn)東京都老人総合研究所; 東京都老人総合研究所; 東京都老人総合研究所; 東京都老人総合研究所
Author Affiliation(eng)Tokyo Metropolitan Institute of Gerontology; Tokyo Metropolitan Institute of Gerontology; Tokyo Metropolitan Institute of Gerontology; Tokyo Metropolitan Institute of Gerontology
Issue Date2006-03
PublisherInstitute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA)
宇宙航空研究開発機構宇宙科学研究本部
Publication titleSpace Utilization Research: Proceedings of Space Utilization Symposium
宇宙利用シンポジウム
Volume22
Publication date2006-03
Languagejpn
eng
AbstractIonizing radiation causes various damages, carcinogenesis or cell death. However, low dose irradiation is reported to give rise to adaptive responses. We have reported that radiation adaptive response was observed in cultured astrocytes from young rats, and that the response was decreased with aging. In order to investigate the mechanisms of radiation adaptive response in cultured astrocytes, in the present study, we analyzed the variant expressions and phosphorylation of proteins in cell using proteomics. As a result, the fragmentation of elongation factor 2 was temporarily increased and elongation factor 1-beta was de-phosphorylated after low dose irradiation.
DescriptionMeeting Information: The Twenty-second Space Utilization Symposium (January 17-19, 2006: Science Council of Japan, Roppongi, Tokyo, Japan)
Meeting sponsors: The Science Council of Japan, The Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency (ISAS)(JAXA)
会議情報: 第22回宇宙利用シンポジウム(2006年1月17日-19日, 日本学術会議6階会議室 六本木、東京)
共催: 日本学術会議
Keywordslow dose radiation, radiation adaptive response, proteomics, phosphorylation, aging, 2-D PAGE
Document TypeConference Paper
JAXA Categoryシンポジウム・研究会
NCIDAN10324210
SHI-NOAA0064113063
URIhttps://repository.exst.jaxa.jp/dspace/handle/a-is/19949


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