JAXA Repository / AIREX 未来へ続く、宙(そら)への英知

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Other TitleStudies on genetic effects of space radiation: Challenge at cellular level
Author(jpn)谷田貝 文夫; 高山 裕子; 井上 正美; 宮本 裕一; 岩木 正哉; 本間 正充
Author(eng)Yatagai, Fumio; Takayama, Yuko; Inoue, Masami; Miyamoto, Yuichi; Iwaki, Masaya; Honma, Masamitsu
Author Affiliation(jpn)理化学研究所; 理化学研究所; 理化学研究所; 理化学研究所; 理化学研究所; 国立医薬品食品衛生研究所
Author Affiliation(eng)Institute of Physical and Chemical Research; Institute of Physical and Chemical Research; Institute of Physical and Chemical Research; Institute of Physical and Chemical Research; Institute of Physical and Chemical Research; National Institute of Health Sciences
Issue Date2005-03
PublisherInstitute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)
Publication title宇宙利用シンポジウム 第21回 平成16年度
Space Utilization Research: Proceedings of the Twenty-first Space Utilization Symposium
Start page263
End page265
Publication date2005-03
AbstractIt is important for development of space utilization to estimate the influences of space radiation on human health and reduce its level as low as possible. For such estimation, the genetic influences of various types of Ionizing Radiation (IR) involved in the space radiation are elucidated, especially at low-dose level. The investigations are based upon the mutation detection system, which is established by using human lymphoblastoid cell TK6. In fact, the observed mutational event, Loss Of Heterozygosity (LOH) was shown to be a good indictor for the influence of low-dose IR including heavy-ions, which are known as major components of space radiation. Recently an effort to estimate the effects of radioadaptation by utilizing the above mutation-system are made because a long stay in space can be considered as a priming treatment in the adaptive response.
Keywordscosmic ray; loss of heterozygosity; double strand break; lymphoblastoid cell; mutation; radiation dosage; cultured cell; ionizing radiation; genetic effect; microbeam; 宇宙線; ヘテロ接合性の損失; 2本鎖切断; リンパ芽球腫細胞; 突然変異; 被曝線量; 培養細胞; 電離放射線; 遺伝的影響; マイクロビーム
Document TypeConference Paper
JAXA Categoryシンポジウム・研究会

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