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titleELF磁場照射がマウス胎子の発生におよぼす影響
Other TitleTeratogenic effects of ELF exposure on the developing mouse embryos
Author(jpn)斉藤 賢一; 村上 寛; 宮原 晋一; 鈴木 浩悦
Author(eng)Saito, Kenichi; Murakami, Hiroshi; Miyabara, Shinichi; Suzuki, Hiroetsu
Author Affiliation(jpn)日本獣医生命科学大学 応用生命科学部; 産業技術総合研究所 エネルギー技術研究部門; 長崎労災病院 病理科; 日本獣医生命科学大学 獣医学部
Author Affiliation(eng)Nippon Veterinary and Life Science University Faculty of Applied Life Science; National Institute of Advanced Industrial Science and Technology Energy Technology Research Institute; Nagasaki Rosai Hospital Department of Pathology; Nippon Veterinary and Life Science University Faculty of Veterinary Science
Issue Date2008-05
PublisherInstitute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)
宇宙航空研究開発機構宇宙科学研究本部
Publication title第27回宇宙エネルギーシンポジウム 平成19年度
The Twenty-seventh Space Energy Symposium
Start page93
End page96
Publication date2008-05
Languagejpn
AbstractRecently, there are many electric appliances in human living environment. Various low frequency electromagnetic fields are emitted from those devices. It have been suspect for a long time that environmental exposure of Extremely Low Frequency ElectroMagnetic Field (ELF-EMF) emitted from the appliances may have harmful biological effects. ELF electromagnetic radiation haves received high interest due to growing concern on the harmful biological effects on both human and animal health. This study describes that ELF-MF (50 Hz) to the pregnant mice has teratogenic effects on the developing embryos. The magnetic field exposed dose of 2.0 mT in this experiment. Fetuses were continuously exposed with alternation magnetic field in utero from 7.5 to 18.5 days of pregnancy. Mice were autopsied on 18.5 days of pregnancy. Control mice received sham exposure with the same schedule as that of exposed. The mouse was sacrificed by overdose ether anesthesia and the fetuses were removed for morphological observation. The skeleton of fetuses was doubly stained with alcian blue and alizarin red S. The specimens were observed under a stereomicroscope. The malformed rates of fetuses of irradiation group increased more significantly than control group. The exposure group had anomalies including gastroschisis and curled tail.
Keywordsextremely low frequency; mouse; embryo; teratogenicity; electromagnetic radiation; pregnancy; protein; gene; mutation; 超低周波数; マウス; 胚; 催奇性; 電磁放射; 妊娠; タンパク質; 遺伝子; 変異
Document TypeConference Paper
JAXA Categoryシンポジウム・研究会
SHI-NOAA0063965019
URIhttps://repository.exst.jaxa.jp/dspace/handle/a-is/37016


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