JAXA Repository / AIREX 未来へ続く、宙(そら)への英知

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Other TitleAcquisition and retention of conditioned taste aversion memory are impaired by pseudo-microgravity environment
Author(jpn)宮本 武典; 藤原 悠美; 坪井 香苗; 藤原 宏子; 木本 万里
Author(eng)Miyamoto, Takenori; Fujiwara, Yumi; Tsuboi, Kanae; EdaFujiwara, Hiroko; Kimoto, Mari
Author Affiliation(jpn)日本女子大学; 日本女子大学; 日本女子大学; 日本女子大学; 日本女子大学
Author Affiliation(eng)Japan Women's University; Japan Women's University; Japan Women's University; Japan Women's University; Japan Women's University
Issue Date2005-03
PublisherInstitute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)
Publication title宇宙利用シンポジウム 第21回 平成16年度
Space Utilization Research: Proceedings of the Twenty-first Space Utilization Symposium
Start page228
End page230
Publication date2005-03
AbstractThe effect of gravitational force on acquisition and retention of the Conditioned Taste Aversion (CTA) paradigm as a model of emotional learning and memory were examined. The Pseudo-Microgravity environment (PMG) was applied between 0.2 percent sodium saccharin as a Conditioned Stimulus (CS) and an intraperitoneal injection of 0.15 M LiCl as an unconditioned stimulus (US) using 3D clinostat to cancel the gravitational force. Although PMG condition did not serve as US, it suppressed both acquisition and retention of CTA Memory (CTAM). Furthermore, after CTAM acquisition with the PMG, expression of an immediately early gene, c-fos was greatly suppressed in the external lateral subnucleus of parabrachial nucleus, which strongly appeared under control condition. These results suggest that the pseudo-microgravity force impairs CTAM memory formation through suppression of neuronal activity in the gustatory pathways of brain stem.
Keywordspseudo-microgravity environment; clinostat; high gravity environment; microgravity; taste aversion; conditioned stimulus; unconditioned stimulus; memory; learning; analysis of variance; 擬似微小重力環境; クリノスタット; 高重力環境; 微小重力; 味覚嫌悪; 条件刺激; 無条件刺激; 記憶; 学習; 分散分析
Document TypeConference Paper
JAXA Categoryシンポジウム・研究会

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