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Other TitleEffects of hindlimb unloading on growth-related changes in cell body size and oxidative enzyme activity of spinal motoneurons innervating the rat tibialis anterior muscle
Author(jpn)石原 昭彦; 河野 史倫; Wang, Xiao Dong; 大平 充宣
Author(eng)Ishihara, Akihiko; Kawano, Fuminori; Wang, Xiao Dong; Ohira, Yoshinobu
Author Affiliation(jpn)京都大学 大学院人間・環境学研究科; 大阪大学 健康体育部; 大阪大学 健康体育部; 大阪大学 健康体育部
Author Affiliation(eng)Kyoto University Graduate School of Human and Environmental Studies; Osaka University School of Health and Sport Sciences; Osaka University School of Health and Sport Sciences; Osaka University School of Health and Sport Sciences
Issue Date2005-03
PublisherInstitute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)
Publication title宇宙利用シンポジウム 第21回 平成16年度
Space Utilization Research: Proceedings of the Twenty-first Space Utilization Symposium
Start page231
End page233
Publication date2005-03
AbstractMale rats were hindlimb-unloaded from postnatal day four to month three. The rats were sacrificed immediately, one, two, and three months after hindlimb reloading. Numbers, cell body sizes, and oxidative enzyme (succinate dehydrogenase) activities of spinal motoneurons innervating the fast tibialis anterior muscle were determined by quantitative enzyme histochemistry. The motoneurons innervating the tibialis anterior muscle were labeled by a retrograde neuronal tracer, nuclear yellow. No changes in number or oxidative enzyme activity of the motoneurons were observed after hindlimb unloading relative to the control level. However, the growth-related increase in cell body size of the motoneurons was inhibited by hindlimb unloading. The inhibited growth of cell body size of the motoneurons was normalized one month after hindlimb reloading. It is concluded that the increase in cell body size of the spinal motoneurons innervating the skeletal muscles during early postnatal growth was inhibited by hindlimb unloading and that the reloading-related recovery of cell body size is faster in the motoneurons innervating the fast skeletal muscle than in those innervating the slow skeletal muscle.
Keywordscell body size; hindlimb suspension; spinal motoneuron; tibialis anterior muscle; enzyme activity; rat; succinate dehydrogenase; musculus soleus; skeletal muscle; neuron; 細胞体サイズ; 後肢懸垂; 脊髄運動ニューロン; 前頚骨筋; 酵素活性; ラット; コハク酸脱水素酵素; ヒラメ筋; 骨格筋; ニューロン
Document TypeConference Paper
JAXA Categoryシンポジウム・研究会

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