JAXA Repository / AIREX 未来へ続く、宙(そら)への英知

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Other TitleActivation mechanism of osteoblast-like cell line induced by mechanostimulation
Author(jpn)行徳 淳一郎; 村上 直子; 高沖 宗夫
Author(eng)Gyotoku, Junichiro; Murakami, Naoko; Takaoki, Muneo
Author Affiliation(jpn)宇宙航空研究開発機構 宇宙科学研究本部 ISS科学プロジェクト室; エイ・イー・エス; 宇宙航空研究開発機構 宇宙基幹システム本部
Author Affiliation(eng)Japan Aerospace Exploration Agency ISS Science Project Office, Institute of Space and Astronautical Science; Advanced Engineering Services Co. Ltd.; Japan Aerospace Exploration Agency Office of Space Flight and Operations
Issue Date2005-03
PublisherInstitute of Space and Astronautical Science, Japan Aerospace Exploration Agency (JAXA/ISAS)
Publication title宇宙利用シンポジウム 第21回 平成16年度
Space Utilization Research: Proceedings of the Twenty-first Space Utilization Symposium
Start page201
End page204
Publication date2005-03
AbstractFluid Flow is one of the most potent mechanical stimulators for bone cells. Recently it is suggested that primary cilia along with ion channels and related molecules play roles in the flow detection in kidney epithelial cells. A question if there is any similarity between kidney cells and bone cells in their flow detection mechanisms arises. Cultured osteoblastic cell line MC3T3-E1 expressed primary cilia. The cells responded to fluid flow, generated by manual rocking of flasks, and expressed c-fos gene. The cells were found to respond not only the flow but also cooling of the culture fluid. It was suggested that bone and kidney cells might share similar mechanisms in flow detection.
Keywordsmechanostimulation; fluid flow; osteoblast; cultured cell; stimulation; cilium; IgG; response; temperature control; 機械刺激; 液流; 骨芽細胞; 培養細胞; 刺激; 繊毛; IgG; 応答; 温度制御
Document TypeConference Paper
JAXA Categoryシンポジウム・研究会

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