JAXA Repository / AIREX 未来へ続く、宙(そら)への英知
63337000.pdf2.78 MB
Other TitleReport of neurophysiology research project in ISS Science Project Office: Effects of hyperbaric exposure with high oxygen concentration on muscle atrophy
Author(jpn)石原 昭彦
Author(eng)Ishihara, Akihiko
Author Affiliation(jpn)京都大学 大学院
Author Affiliation(eng)Kyoto University Graduate School
Issue Date2007-03-30
PublisherJapan Aerospace Exploration Agency (JAXA)
Publication date2007-03-30
AbstractEffects of hyperbaric exposure with high oxygen concentration on the physical activity and neuromuscular system of developing male rats were investigated. Five-week-old male rats were exposed to an atmospheric pressure of 1.25 with an oxygen concentration of 36 percent for 12 h (7:00-19:00) and exercised voluntarily for 12 h (19:00-7:00) daily for eight weeks. The voluntary running distances were compared with those in age-matched rats without hyperbaric exposure. Furthermore, the properties of the soleus and plantaris muscle fibers and their spinal motoneurons were examined. The voluntary running distances of rats with or without hyperbaric exposure with high oxygen concentration increased during development. However, the mean voluntary running distances were 1.44-hold longer in rats with hyperbaric exposure than in those without hyperbaric exposure. The oxidative enzyme activities of the soleus and plantaris muscle fibers and their spinal motoneurons increased following hyperbaric exposure with high oxygen concentration. It is suggested that adaptations of neuromuscular units to hyperbaric exposure with high oxygen concentration enhance the oxidative metabolism and thus the function of neuromuscular units is promoted.
DescriptionJAXA Special Publication
Keywordsmanned space flight; ISS; spacecraft environment; hyperbaric exposure; hyperoxic exposure; partial pressure; neurophysiology; rat; physical exercise; skeletal muscle; muscle atrophy; 有人宇宙飛行; ISS; 宇宙機環境; 高気圧曝露; 高濃度酸素曝露; 分圧; 神経生理学; ラット; 運動; 骨格筋; 筋萎縮
Document TypeTechnical Report
JAXA Category特別資料
Report NoJAXA-SP-06-031

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.