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titleISS科学プロジェクト室神経生理研究プロジェクト研究開発報告書:筋萎縮に対する高気圧・高濃度酸素の影響
Other TitleReport of neurophysiology research project in ISS Science Project Office: Effects of hyperbaric exposure with high oxygen concentration on muscle atrophy
Author(jpn)石原 昭彦
Author(eng)Ishihara, Akihiko
Author Affiliation(jpn)京都大学 大学院
Author Affiliation(eng)Kyoto University Graduate School
Issue Date2007-03-30
PublisherJapan Aerospace Exploration Agency (JAXA)
宇宙航空研究開発機構
Publication date2007-03-30
Languagejpn
AbstractEffects of hyperbaric exposure with high oxygen concentration on the physical activity and neuromuscular system of developing male rats were investigated. Five-week-old male rats were exposed to an atmospheric pressure of 1.25 with an oxygen concentration of 36 percent for 12 h (7:00-19:00) and exercised voluntarily for 12 h (19:00-7:00) daily for eight weeks. The voluntary running distances were compared with those in age-matched rats without hyperbaric exposure. Furthermore, the properties of the soleus and plantaris muscle fibers and their spinal motoneurons were examined. The voluntary running distances of rats with or without hyperbaric exposure with high oxygen concentration increased during development. However, the mean voluntary running distances were 1.44-hold longer in rats with hyperbaric exposure than in those without hyperbaric exposure. The oxidative enzyme activities of the soleus and plantaris muscle fibers and their spinal motoneurons increased following hyperbaric exposure with high oxygen concentration. It is suggested that adaptations of neuromuscular units to hyperbaric exposure with high oxygen concentration enhance the oxidative metabolism and thus the function of neuromuscular units is promoted.
高気圧・高濃度酸素への曝露がラットの活動量と神経・筋の特性にどのような影響を及ぼすのかを検討した。生後5週齢の雄ラットを午前7時から午後7時まで12時間にわたって1.25気圧、酸素濃度36%の環境に曝露し、午後7時から午前7時までは回転車輪の附属した運動装置で飼育した(高気圧群)。また、対照群のラットは、午前7時から午後7時までは普通飼育を行い、午後7時から午前7時までは回転車輪の附属した運動装置で飼育した。8週間後に走運動量、ヒラメ筋と足底筋の筋線維の特性、それらの筋線維を神経支配する脊髄の運動ニューロンの特性を検討した。高気圧群の走運動量は、対照群と比較して1.44倍であった。ヒラメ筋と足底筋の筋線維とそれらを神経支配する運動ニューロンで酸化系酸素活性が増大した。本研究で用いた高気圧・高濃度酸素は有酸素代謝を増大させ、その結果、神経・筋の酸化能力が向上して走運動量が増大したと推察される。
DescriptionJAXA Special Publication
宇宙航空研究開発機構特別資料
Keywordsmanned space flight; ISS; spacecraft environment; hyperbaric exposure; hyperoxic exposure; partial pressure; neurophysiology; rat; physical exercise; skeletal muscle; muscle atrophy; 有人宇宙飛行; ISS; 宇宙機環境; 高気圧曝露; 高濃度酸素曝露; 分圧; 神経生理学; ラット; 運動; 骨格筋; 筋萎縮
Document TypeTechnical Report
JAXA Category特別資料
ISSN1349-113X
SHI-NOAA0063337000
Report NoJAXA-SP-06-031
URIhttps://repository.exst.jaxa.jp/dspace/handle/a-is/46763


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