| タイトル | Pulsatile Fluid Shear in Bone Remodeling |
| 本文（外部サイト） | http://hdl.handle.net/2060/19970022809 |
| 著者（英） | Frangos, John A. |
| 著者所属（英） | California Univ., San Diego |
| 発行日 | 1997-01-01 |
| 言語 | eng |
| 内容記述 | The objective of this investigation was to elucidate the sensitivity to transients in fluid shear stress in bone remodeling. Bone remodeling is clearly a function of the local mechanical environment which includes interstitial fluid flow. Traditionally, load-induced remodeling has been associated with low frequency (1-2 Hz) signals attributed to normal locomotion. McLeod and Rubin, however, demonstrated in vivo remodeling events associated with high frequency (15-30 Hz) loading. Likewise, other in vivo studies demonstrated that slowly applied strains did not trigger remodeling events. We therefore hypothesized that the mechanosensitive pathways which control bone maintenance and remodeling are differentially sensitive to varying rates of applied fluid shear stress. |
| NASA分類 | Aerospace Medicine |
| レポートNO | 97N23248
NASA-CR-204942
NAS 1.26:204942 |
| 権利 | No Copyright |
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