| タイトル | Cytokines and macrophage function in humans - role of stress |
| 本文（外部サイト） | http://hdl.handle.net/2060/19960026766 |
| 著者（英） | Sonnenfeld, Gerald |
| 著者所属（英） | Carolinas Medical Center |
| 発行日 | 1996-05-01
1996 |
| 言語 | eng |
| 内容記述 | We have begun this study to commence the determination of the role of mild chronic stress in the effects of space flight on macrophage/monocyte function, a component of the immune response. Medical students undergoing regular periods of stress and relaxation have been shown to be an excellent model for determining the effects of stress on immune responses. We have begun using this model using the macrophage/monocyte as model leukocyte. The monocyte/macrophage plays a central role in immunoregulation. The studies to be included in this three year project are the effects of stress on: (1) interactions of monocytes with microbes, (2) monocyte production of cytokines, (3) monocyte phagocytosis and activity, and (4) monocyte expression of cell surface antigens important in immune responses. Stress hormone levels will also be carried out to determine if there is a correlation between stress effects on immune responses and hormonal levels. Psychological testing to insure subjects are actually stressed or relaxed at the time of testing will also be carried out. The results obtained from the proposed studies should be comparable with space flight studies with whole animals and isolated cell cultures. When complete this study should allow the commencement of the establishment of the role of stress as one compartment of the induction of immune alterations by space flight. |
| NASA分類 | Aerospace Medicine |
| レポートNO | 96N28326
NASA-CR-201019
NAS 1.26:201019 |
| 権利 | No Copyright |
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