| タイトル | Three-dimensional structure of human serum albumin |
| 本文（外部サイト） | http://hdl.handle.net/2060/19910014744 |
| 著者（英） | Twigg, Pamela D.; He, Xiao-Min; Casale, Elena; Carter, Daniel C. |
| 著者所属（英） | NASA Marshall Space Flight Center |
| 発行日 | 1991-01-01 |
| 言語 | eng |
| 内容記述 | The binding locations to human serum albumin (HSA) of several drug molecules were determined at low resolution using crystallographic methods. The principal binding sites are located within subdomains IIA and IIIA. Preliminary studies suggest that an approach to increasing the in vivo efficacy of drugs which are rendered less effective or ineffective by virtue of their interaction with HSA, would be the use of competitive displacement in drug therapies and/or the development of a general inhibitor to the site within subdomain IIIA. These findings also suggest that the facilitated transfer of various ligands across organ/circulatory interfaces such as liver, kidney, and brain may be associated with binding to the IIIA subdomain. |
| NASA分類 | AEROSPACE MEDICINE |
| レポートNO | 91N24057 |
| 権利 | No Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/132533 |
