| タイトル | Dexamethasone regulates glutamine synthetase expression in rat skeletal muscles |
| 本文（外部サイト） | http://hdl.handle.net/2060/19880015745 |
| 著者（英） | Vitkovic, Ljubisa; Banner, Carl; Konagaya, Yoko; Thomas, John W.; Max, Stephen R.; Konagaya, Masaaki |
| 著者所属（英） | Maryland Univ. |
| 発行日 | 1986-01-01 |
| 言語 | eng |
| 内容記述 | The regulation of glutamine synthetase by glucocorticoids in rat skeletal muscles was studied. Administration of dexamethasone strikingly enhanced glutamine synthetase activity in plantaris and soleus muscles. The dexamethasone-mediated induction of glutamine synthetase activity was blocked to a significant extent by orally administered RU38486, a glucocorticoid antagonist, indicating the involvement of intracellular glucocorticoid receptors in the induction. Northern blot analysis revealed that dexamethasone-mediated enhancement of glutamine synthetase activity involves dramatically increased levels of glutamine synthetase mRNA. The induction of glutamine synthetase was selective in that glutaminase activity of soleus and plantaris muscles was not increased by dexamethasone. Furthermore, dexamethasone treatment resulted in only a small increase in glutamine synthetase activity in the heart. Accordingly, there was only a slight change in glutamine synthetase mRNA level in this tissue. Thus, glucocorticoids regulate glutamine synthetase gene expression in rat muscles at the transcriptional level via interaction with intracellular glutamine production by muscle and to mechanisms underlying glucocorticoid-induced muscle atrophy. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 88N25129
NASA-CR-182935
NAS 1.26:182935 |
| 権利 | No Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/145962 |
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