| タイトル | Changes in bone structure and metabolism during simulated weightlessness: Endocrine and dietary factors |
| 本文（外部サイト） | http://hdl.handle.net/2060/19850021209 |
| 著者（英） | Wronski, T. J.; Halloran, B. P. |
| 著者所属（英） | Veterans Administration Hospital |
| 発行日 | 1985-01-01 |
| 言語 | eng |
| 内容記述 | The role of vitamin D, PTH and corticosterone in the skeletal alterations induced by simulated weightlessness was examined. The first objective was to determine if changes in the serum concentrations of Ca, P sub i, osteocalcin, 25-OH-D, 24,25(OH)2D or 1,25(OH)2D also occur following acute skeletal unloading. Animals were either suspended or pair fed for 2, 5, 7, 10, 12 and 15 days and the serum concentrations of Ca, P sub i, osteocalcin and the vitamin D metabolites measured. Bone histology was examined at day 5 after suspension. Acute skeletal unloading produced a transient hypercalcemia, a significant fall in serum osteocalcin and serum 1,25(OH)2D, a slight rise in serum 24,25(OH)2D, but did not affect the serum concentrations of P sub i or 25-OH-D. At the nadir in serum 1,25(OH)2D serum osteocalcin was reduced by 22%, osteoblast surface by 32% and longitudinal bone growth by 21%. |
| NASA分類 | AEROSPACE MEDICINE |
| レポートNO | 85N29521
NAS 1.26:175961
NASA-CR-175961 |
| 権利 | No Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/156160 |
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