タイトル | Modulation of Hippocampal Proteins by Exposure to Simulated Microgravity Environment during the Postnatal Development in Rats |
著者(日) | 尾家, 慶彦; 河野, 史倫; 野村, 幸子; 大平, 宇志; 藤田, 諒; 寺田, 昌弘; 芝口, 翼; 中井, 直也; 大平, 充宣 |
著者(英) | Oke, Yoshihiko; Kawano, Fuminori; Nomura, Sachiko; Ohira, Takashi; Fujita, Ryo; Terada, Masahiro; Shibaguchi, Tsubasa; Nakai, Naoya; Ohira, Yoshinobu |
著者所属(日) | 大阪大学大学院医学系研究科; 大阪大学大学院医学系研究科; 大阪大学大学院医学系研究科; 大阪大学大学院生命機能研究科; 大阪大学大学院医学系研究科; 大阪大学大学院生命機能研究科; 大阪大学大学院生命機能研究科; 大阪大学大学院医学系研究科; 大阪大学大学院医学系研究科 : 大阪大学大学院生命機能研究科 |
著者所属(英) | Graduate School of Medicine, Osaka University; Graduate School of Medicine, Osaka University; Graduate School of Medicine, Osaka University; Graduate School of Frontier Biosciences, Osaka University; Graduate School of Medicine, Osaka University; Graduate School of Frontier Biosciences, Osaka University; Graduate School of Frontier Biosciences, Osaka University; Graduate School of Medicine, Osaka University; Graduate School of Medicine, Osaka University : Graduate School of Frontier Biosciences, Osaka University |
発行日 | 2011-09-01 |
発行機関など | 日本宇宙航空環境医学会 Japan Society of Aerospace and Environmental Medicine |
刊行物名 | 宇宙航空環境医学 Japanese Journal of Aerospace and Environmental Medicine |
巻 | 48 |
号 | 3 |
開始ページ | 23 |
終了ページ | 34 |
刊行年月日 | 2011-09-01 |
言語 | eng |
抄録 | Effects of 14 days of hindlimb suspension and 14 days of ambulation recovery on the hippocampus proteome were investigated in 3-week old male Wistar Hannover rats during postnatal developing stage. Hindlimb suspension caused increased and decreased expression of 4 and 6 proteins, respectively. All of these proteins are reported to have functions related to cellular protection, cell death, neurogenesis, neural activity, or neuronal circuitry formation. In order to reveal whether post-translational modifications are altered, we further studied isoelectric point profiles of the 3 proteins (protein disulfide isomerase A3, triosephosphate isomerase 1, and sirtuin 2) involved in cell death or neuronal circuitry formation. Each of the 3 proteins indicated different spot patterns between the control and hindlimb-suspended groups. Furthermore, the altered profiles of proteins were not normalized to the age-matched control levels after 14 days of recovery. These results suggest that hindlimb suspension during the postnatal development of the brain might induce an inappropriate cell survival and abnormal neuronal circuitry, followed by disorder in the hippocampus function. |
内容記述 | 形態: 図版あり Physical characteristics: Original contains illustrations |
キーワード | Microgravity; Hindlimb suspension; Proteome; Hippocampus; Postnatal developing rat |
資料種別 | Journal Article |
NASA分類 | Aerospace Medicine |
ISSN | 0387-0723 |
NCID | AN00019323 |
SHI-NO | AA0065419001 |
URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/16147 |
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