| タイトル | Testosterone enhances C-14 2-deoxyglucose uptake by striated muscle |
| 本文（外部サイト） | http://hdl.handle.net/2060/19820021110 |
| 著者（英） | Toop, J.; Max, S. R. |
| 著者所属（英） | Maryland Univ. |
| 発行日 | 1982-01-01 |
| 言語 | eng |
| 内容記述 | The effect of testosterone propionate (TP) on C-14 2-deoxyglucose (C-14 2DG) uptake was studied in the rat levator ani muscle in vivo using the autoradiographic technique. Following a delay of 1 to 3 h after injecting TP, the rate of C-14 2DG uptake in experimental animals began to increase and continued to increase for at least 20 h. The label, which corresponds to C-14 2-deoxyglucose 6-phosphate, as demonstrated by chromatographic analysis of muscle extracts, was uniformly distributed over the entire muscle and was predominantly in muscle fibers, although nonmuscular elements were also labeled. The 1 to 3 h time lag suggests that the TP effect may be genomic, acting via androgen receptors, rather than directly on muscle membranes. Acceleration of glucose uptake may be an important early event in the anabolic response of the rat levator ani muscle to androgens. |
| NASA分類 | AEROSPACE MEDICINE |
| レポートNO | 82N28986
NASA-CR-169101
NAS 1.26:169101 |
| 権利 | No Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/165344 |
|
