| タイトル | Effects of Spaceflight and Hindlimb Suspension on the Posture and Gait of Rats |
| 著者（英） | Corcoran, M.; Daunton, N. G.; Fox, R. A.; Morey-Holton, E. |
| 著者所属（英） | NASA Ames Research Center |
| 発行日 | 1994-01-01 |
| 言語 | eng |
| 内容記述 | Instability of posture and gait in astronauts following spaceflight (SF) is thought to result from muscle atrophy and from changes in sensory-motor integration in the CNS (central nervous system) that occur during adaptation to microgravity (micro-G). Individuals are thought to have developed, during SF, adaptive changes for the processing of proprioceptive, vestibular and visual sensory inputs with reduced weighting of gravity-based signals and increased weighting of visual and tactile cues. This sensory-motor rearrangement in the CNS apparently occurs to optimize neuromuscular system function for effective movement and postural control in micro-G. However, these adaptive changes are inappropriate for the 1 g environment and lead to disruptions in posture and gait on return to Earth. Few reports are available on the effects of SF on the motor behavior of animals. Rats studied following 18.5 - 19.5 days of SF in the COSMOS program were described as being ..'inert, apathetic, slow'.. and generally unstable. The hindlimbs of these rats were ..'thrust out from the body with fingers pulled apart and the shin unnaturally pronated'. On the 6th postflight day motor behavior was described as similar to that observed in preflight observations. Improved understanding of the mechanisms leading to these changes can be obtained in animal models through detailed analysis of neural and molecular mechanisms related to gait. To begin this process the posture and gait of rats were examined following exposure to either SF or hindlimb suspension (HLS), and during recovery from these conditions. |
| NASA分類 | Life Sciences (General) |
| 権利 | No Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/225684 |
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