| タイトル | Modularized TGFbeta-Smad Signaling Pathway |
| 本文（外部サイト） | http://hdl.handle.net/2060/20110014110 |
| 著者（英） | Li, Yongfeng; Cucinotta, F. A.; Carra, C.; Wang, M. |
| 著者所属（英） | NASA Johnson Space Center |
| 発行日 | 2011-01-01 |
| 言語 | eng |
| 内容記述 | The Transforming Growth Factor beta (TGFbeta) signaling pathway is a prominent regulatory signaling pathway controlling various important cellular processes. It can be induced by several factors, including ionizing radiation. It is regulated by Smads in a negative feedback loop through promoting increases in the regulatory Smads in the cell nucleus, and subsequent expression of inhibitory Smad, Smad7 to form a ubiquitin ligase with Smurf targeting active TGF receptors for degradation. In this work, we proposed a mathematical model to study the radiation-induced Smad-regulated TGF signaling pathway. By modularization, we are able to analyze each module (subsystem) and recover the nonlinear dynamics of the entire network system. Meanwhile the excitability, a common feature observed in the biological systems, along the TGF signaling pathway is discussed by mathematical analysis and numerical simulation. |
| NASA分類 | Life Sciences (General) |
| レポートNO | JSC-CN-24290 |
| 権利 | Copyright, Distribution as joint owner in the copyright |
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