| タイトル | Cardiac and Vascular Responses to Thigh Cuffs and Respiratory Maneuvers on Crewmembers of the International Space Station |
| 本文（外部サイト） | http://hdl.handle.net/2060/20110010986 |
| 著者（英） | Feiveson, Alan; Sargsyan, Ashot E.; Duncan, J. Michael; Hamilton, Douglas; Dulchavsky, Scott A.; Ebert, Douglas; Bogomolov, Valery V.; Whitson, Peggy A.; Garcia, Kathleen; Alferova, Irina V.; Matveev, Vladimir P. |
| 著者所属（英） | NASA Johnson Space Center |
| 発行日 | 2011-04-11 |
| 言語 | eng |
| 内容記述 | The transition to microgravity eliminates the hydrostatic gradients in the vascular system. The resulting fluid redistribution commonly manifests as facial edema, engorgement of the external neck veins, and a decrease in leg diameter. This experiment examined the responses to modified Valsalva and Mueller maneuvers measured by cardiac and vascular ultrasound (ECHO) in a baseline steady state and during preload reduction introduced with thigh occlusion cuffs used as a counter-measure device (Braslet cuffs) measured by cardiac and vascular ultrasound examinations. Methods: Nine International Space Station crewmember subjects (Expeditions 16 - 20) were examined in 15 experiment sessions 101 +/- 46.days after launch (mean +/- SD; 33 - 185). Twenty Seven cardiac and vascular parameters were obtained with/without respiratory maneuvers before and after tightening of the Braslet cuffs. Results: Non-physicians performed diagnostic-quality cardiac and vascular ultrasound examinations using remote guidance. Three of 27 combinations of maneuvers and Braslet or Braslet alone were identified as being significant changed when compared to baseline. Eleven of 81 differences between combinations of Mueller, Valsalva or baseline were significant and related to cardiac preload reduction or increase in lower extremity venous volume. Conclusions: Acute application of Braslet occlusion cuffs causes lower extremity fluid sequestration and exerts commensurate measurable effects on cardiac performance in microgravity. Ultrasound techniques to measure the hemodynamic effects of thigh cuffs in combination with respiratory maneuvers may serve as an invaluable tool in determining the volume status of the cardiac patient at the 'microgravity bedside'. |
| NASA分類 | Aerospace Medicine |
| レポートNO | JSC-CN-23468 |
| 権利 | Copyright, Distribution as joint owner in the copyright |
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