| タイトル | Advanced Electrocardiographic Predictors of Sudden Death in Familial Dysautonomia |
| 本文（外部サイト） | http://hdl.handle.net/2060/20070030843 |
| 著者（英） | Starc, V.; Marthol, H.; Solaimanzadeh, I.; Tutaj, M.; Schlegel, T. T.; Buechner, S.; Greco, E. C.; Axelrod, F. B.; Hilz, M. J.; DePalma, J. L. |
| 著者所属（英） | NASA Johnson Space Center |
| 発行日 | 2007-01-01 |
| 言語 | eng |
| 内容記述 | To identify accurate predictors for the risk of sudden death in patients with familial dysautonomia (FD). Ten-minute resting high-fidelity 12-lead ECGs were obtained from 14 FD patients and 14 age/gender-matched healthy subjects. Multiple conventional and advanced ECG parameters were studied for their ability to predict sudden death in FD over a subsequent 4.5-year period, including multiple indices of linear and non-linear heart rate variability (HRV); QT variability; waveform complexity; high frequency QRS; and derived Frank-lead parameters. Four of the 14 FD patients died suddenly during the follow-up period, usually with concomitant pulmonary disorder. The presence of low vagally-mediated HRV was the ECG finding most predictive of sudden death. Concomitant left ventricular hypertrophy and other ECG abnormalities such as increased QTc and JTc intervals, spatial QRS-T angles, T-wave complexity, and QT variability were also present in FD patients, suggesting that structural heart disease is fairly common in FD. Although excessive or unopposed cardiac vagal (relative to sympathetic) activity has been postulated as a contributor to sudden death in FD, the presence of low vagally-mediated HRV was paradoxically the best predictor of sudden death. However, we suggest that low vagally-mediated HRV be construed not as a direct cause of sudden death in FD, but rather as an effect of concurrent pathological processes, especially hypoxia due to pulmonary disorders and sleep apnea, that themselves increase the risk of sudden death in FD and simultaneously diminish HRV. We speculate that adenosine may play a role in sudden death in FD, possibly independently of vagal activity, and that adenosine inhibitors such as theophylline might therefore be useful as prophylaxis in this disorder. |
| NASA分類 | Life Sciences (General) |
| 権利 | Copyright, Distribution as joint owner in the copyright |
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