| タイトル | Skeletal muscle atrophy in response to 14 days of weightlessness - Vastus medialis |
| 著者（英） | Oganov, V. W.; Dombrowski, M. J.; Fell, R. D.; Il'ina-Kakueva, E. I.; Steffen, J. M.; Musacchia, X. J. |
| 著者所属（英） | NASA Ames Research Center |
| 発行日 | 1992-08-01 |
| 言語 | eng |
| 内容記述 | The vastus medialis (VM) response from rats after 14 days of microgravity on Cosmos 2044 (F) have been studied by comparing it with VM from tail-suspended hindlimb-unloaded rats (T) and ground controls. The experimental approaches encompassed a histochemical evaluation of microscopic morphology, including fibers and capillaries; an assessment of biochemical composition including protein, DNA, and RNA concentrations; and an estimation of metabolic capacity. It is concluded that some significant changes were observed in the VM in rats exposed to weightlessness for 14 days. There is a loss in weight compared with the vivarium controls but not in comparison with synchronous and basal controls. Although there were minimal muscle weight differences between groups, muscle weight may be a less sensitive measure of change or atrophy than fiber area measurements. It is suggested that the nonload-bearing muscles, including the VM, show measurable responses to weightless flight. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 92A51477 |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/268513 |
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