| タイトル | Lower Body Negative Pressure Treadmill Exercise and Resistive Exercise Countermeasures Maintain Physiologic Function in Women during Simulated Microgravity |
| 著者（英） | Smith, Scott M.; Lee, S. M. C.; Watenpaugh, D. E.; Hargens, A. R.; Schneider, S. M.; Guinet, P.; Hughson, R. L.; Macias, B. R. |
| 著者所属（英） | NASA Johnson Space Center |
| 発行日 | 2008-01-01 |
| 言語 | eng |
| 内容記述 | We hypothesized that supine LBNP treadmill exercise combined with Flywheel resistive exercise maintains upright physiologic responses following 60-days of head-down tilt (HDT) bed rest (BR). METHODS: 16 healthy women (age 25-40 years) underwent 60-days HDT (-6deg.) BR. Women were assigned to either a non-exercise control group (CON, n=8) or to an exercise group (EX, n=8). EX subjects performed a 40-min, variable intensity LBNP exercise protocol at foot-ward forces between 1.0-1.1 times body weight, followed by 10- min of resting LBNP 3-4 days/week. Resistive exercise of maximal concentric and eccentric supine leg press and heel raise exercises were performed using a flywheel ergometer 2-3 days/week. IRBs approved this study with informed/written consent. RESULTS: Post-BR VO2pk was not different in EX (-3.3+/-1.2%) but decreased significantly in CON (-21.2+/-2.1%), p< 0.05. Post-BR orthostatic tolerance time (mean se) decreased significantly less in EX (19.3+/-1.3 to 14.4+/-1.5 min) than in CON (17.5+/-0.1 to 9.1+/- 1.5 min), p=0.03. Post-BR muscle strength decreased significantly in CON, but was preserved in EX. Post-BR bone resorption was greater than pre-BR in both groups (p<0.05). Bone formation markers, were significantly elevated (p<0.05) in EX than in CON. CONCLUSIONS: Supine LBNP treadmill exercise along with flywheel resistive exercise maintains upright exercise capacity, orthostatic responses and muscle strength during 60-days HDT BR. |
| NASA分類 | Aerospace Medicine |
| レポートNO | WISE-200 |
| 権利 | Copyright |
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