| タイトル | Experiment "Regeneration" Performed Aboard the Russian Spacecraft Foton-M2 in 2005 |
| 著者（英） | Mitashov, Victor; Domaratskaya, Elena; Poplinskaya, Valentina; Grigoryan, Elonora; Almeida, Eduardo; Tairbekov, Murad; Aleinikova, Karina |
| 著者所属（英） | NASA Ames Research Center |
| 発行日 | 2006-07-01 |
| 言語 | eng |
| 内容記述 | The experiments on the newts performed earlier aboard Russian biosate llites showed that the rate of lens and tail regeneration in space wa s greater than on the ground. In parallel it was found that the numbe r of cells in S-phase was greater in space-flown animals than in the ground controls. However, it was unclear whether cell proliferation stimulation was induced by micro-g per se. Molecular mechanisms under lying the change also remained obscure. These issues were addressed b y the joint Russian-American experiment "Regeneration" flown on Foton -M2 in 2005. The method for in-flight delivering DNA precursor BrdU was developed. The experiment showed that during the flight the numbe r of S-phase cells in the regenerating eyes and tails increased. Thes e data together with those obtained earlier suggest that cell prolife ration increases in response to the effects of both micro-g and 1-g a fter return to Earth. The expression of bFGF in regenerating tissues of "flown" newts and ground controls was examined using immuno-histo chemistry. Obtained results suggest that this growth factor is a part icipant of the promotional effect of space flight upon cell prolifera tion in lens and tail regenerates. |
| NASA分類 | Aerospace Medicine |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/275890 |
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