Heat-induced edema in rats, in special reference to contribution of neurogenic inflammation

Abstract

The contribution of neurogenic inflammation in the development of edema from a burn injury induced by hot water at 55 C for 30 s was studied in Sprague-Dawley rats. The magnitude of the heat-induced extravasation measured by an exudation of Evans blue was much stronger in the foot than in the back where innervation density was low. Post-burn foot volume changes were not different between the nerve-intact rats subjected to sciatic and saphenus nerve denervation, demonstrating that the neurogenic component is negligible in its contribution to heat edema under this burn condition.

30秒間、55度Cの熱湯で誘発される熱傷から発生する水腫における神経性炎症の寄与を、Sprague-Dawleyラットで研究した。エバンスブルーの滲出により測定した熱誘発溢出の大きさは、神経支配の密度が低い背中よりも、足の方が強いのが観察された。熱傷後の足の体積変化は、脱神経座骨による神経が無傷のラットと伏在脱神経ラットとの間に差が見られず、この熱傷下での熱炎症に対する神経性成分の寄与が無視出来ることを示した。