| タイトル | Effects of Hypergravity Rearing on Growth Hormone and Insulin-Like Growth Factor in Rat Pups |
| 著者（英） | Baer, L. A.; Wade, C. E.; Chowdhury, J. H.; Grindeland, R. E.; Ronca, A. E. |
| 著者所属（英） | NASA Ames Research Center |
| 発行日 | 2003-07-01 |
| 言語 | eng |
| 内容記述 | Body weights of rat pups reared during exposure to hypergravity (hg) are significantly reduced relative to 1 g controls. In the present study, we examined in hg-reared rat pups two major contributors to growth and development, namely growth hormone (GH) and insulin-like growth factor-1 (IGF-1). Beginning on Gestational day (G)11 of the rats 22 day pregnancy, rat dams and their litters were continuously exposed to either 1.5-g or 2.0-g. On Postnatal day (P)l0, plasma GH and IGF-1 were analyzed using radioimmunoassay (RIA). Both hormones were significantly elevated in hg pups relative to 1-g control pups. Together, these findings suggest that GH and IGF-1 are not primary determinants of reduced body weights observed in hg-reared pups. The significant elevations in pup GH and IGF-1 may be related to increased physical stimulation in hypergravity. |
| NASA分類 | Life Sciences (General) |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/303481 |
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