| タイトル | Influence of spaceflight on the production of interleukin-3 and interleukin-6 by rat spleen and thymus cells |
| 著者（英） | Sonnefeld, Gerald; Koebel, D. Anne; Miller, Edwin S. |
| 著者所属（英） | NASA Ames Research Center |
| 発行日 | 1995-03-01 |
| 言語 | eng |
| 内容記述 | Six adult male Sprague-Dawley rats were flown on the 7-day US space shuttle mission STS-54. After flight, the spleen and thymus from each animal were assayed for the capacity to secrete the cytokines interleukin-3 (IL-3) and IL-6. Spleen and thymus cells were incubated for 48 h in the presence of 5 microgram/ml of concanavalin A or 2 microgram/ml of bacterial lipopolysaccharide to stimulate the production of IL-3 and IL-6. IL-3 activity was measured using the IL-3/colony-stimulating-factor-dependent cell line 32D. IL-6 activity was measured using the IL-6-dependent cell line 7TD1. Spleen and thymus cells harvested from flown rats secreted significantly higher titers of biologically active IL-3 compared with ground control rats. Spaceflight significantly enhanced IL-6 production by thymus, but not spleen, cells. The results of this study demonstrate that spaceflight can enhance the production of certain cytokines by cells of the immune system. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 95A81928 |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/307583 |
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