| タイトル | Interleukin-2 therapy reverses some immunosuppressive effects of skeletal unloading |
| 著者（英） | Armstrong, Jason W.; Chapes, Stephen K.; Balch, Signe |
| 著者所属（英） | NASA Headquarters |
| 発行日 | 1994-08-01 |
| 言語 | eng |
| 内容記述 | Using antiorthostatic suspension, we characterized hematopoietic changes that may be responsible for the detrimental effect of skeletal unloading on macrophage development. Skeletally unloaded mice had suppressed macrophage development in unloaded and loaded bones, which indicated a systemic effect. Bone marrow cells from unloaded mice secreted less macrophage colony-stimulating factor and interleukin-6 than control mice. Additionally, T-lymphocyte proliferation was reduced after skeletal unloading. We show that polyethylene glycol-interleukin-2 therapy reversed the effects of skeletal unloading on macrophage development and cell proliferation. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 95A68896 |
| 権利 | Copyright |
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