| タイトル | Effect of leaving group on the oligomerization of 5'-AMP on montmorillonite |
| 著者（英） | Ferris, James P.; Prabahar, K. Joseph |
| 著者所属（英） | NASA Headquarters |
| 発行日 | 1994-06-01 |
| 言語 | eng |
| 内容記述 | The oligomerization of imidazole derivative of 5'-AMP (ImpA) in the presence of montmorillonite clay yields oligomers containing up to 10 monomer units. In these reactions, the heterocyclic base, imidazole is the leaving group. In our present study, we synthesized a series of activated nucleotides of 5'AMP using other leaving groups such as pyrazole, 1,2,4-triazole, piperidine, morpholine, 4-aminopyridine, 4-methylaminopyridine, 4-dimethylaminopyridine, 2-aminobenzimidazole etc. to determine the effect of amine leaving group on the products of the oligomerization reaction. Earlier results from our laboratory showed that the presence AppA in the clay reaction of ImpA enhances the oligomerization reaction to yield higher oligomers. We also studied the effect of AppA in the clay mediated oligomerization reaction of the activated nucleotides. Oligomerization of 2-amino-benzimidazole derivative of 5'-AMP gave higher oligomers containing up to nine monomer units in the presence of AppA. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 95A63834 |
| 権利 | Copyright |
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