| タイトル | Acute effects of hindlimb unweighting on satellite cells of growing skeletal muscle |
| 著者（英） | Macius, Allison; Darr, Kevin C.; Schultz, Edward |
| 著者所属（英） | NASA Ames Research Center |
| 発行日 | 1994-01-01 |
| 言語 | eng |
| 内容記述 | The proliferative behavior of satellite cells in growing rat soleus and extensor digitorum longus muscles was examined at short periods after initiation of hindlimb unweighting. Mitotic activity of satellite cells in both muscles decreased below weight-bearing control levels within 24 h of initiation of hindlimb unweighting. This satellite cell response was equal to or greater than 48 h before any atrophic morphological changes that take place in the muscles. Suppression of mitotic activity was most severe in the soleus muscle where continuous infusion of label demonstrated that virtually all mitotic activity was abolished between 3 and 5 days. The results of this study suggest that satellite cell mitotic activity is a sensitive indicator of primary atrophic changes occurring in growing myofibers and may be a predictor of future morphological changes. |
| NASA分類 | AEROSPACE MEDICINE |
| レポートNO | 95A61910 |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/311060 |
