| タイトル | Fluence-based relative biological effectiveness for charged particle carcinogenesis in mouse Harderian gland |
| 著者（英） | Deguzman, R.; Power-Risius, P.; Curtis, S. B.; Alpen, E. L.; Fry, R. J. M. |
| 著者所属（英） | NASA Headquarters |
| 発行日 | 1994-10-01 |
| 言語 | eng |
| 内容記述 | Neoplasia in the rodent Harderian gland has been used to determine the carcinogenic potential of irradiation by HZE particles. Ions from protons to lanthanum at energies up to 670 MeV/a have been used to irradiate mice, and prevalence of Harderian gland tumors has been measured 16 months after irradiation. The Relative Biological Effectiveness (RBE) for tumor induction has been expressed as the RBE(sub max), which is the ratio of the initial slopes of the dose vs prevalence curve. The RBE(sub max) has been found to be approximately 30 for ions with Linear Energy Transfer (LET) values in excess of 100 keV/micrometer. Analysis on the basis of fluence as a substitute for dose has shown that on a per particle basis all of the ions with LET values in excess of 100 keV/micrometer have equal effectiveness. An analysis of the probabilities of ion traversals of the nucleus has shown that for these high stopping powers that a single hit is effective in producing neoplastic transformation. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 94A62533 |
| 権利 | Copyright |
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