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タイトルAtomic structure and chemistry of human serum albumin
著者（英）Carter, Daniel C.; He, Xiao M.
著者所属（英）NASA Headquarters; NASA Marshall Space Flight Center
発行日1992-07-16
言語eng
内容記述The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 A. It comprises three homologous domains that assemble to form a heart-shaped molecule. Each domain is a product of two subdomains that possess common structural motifs. The principal regions of ligand binding to human serum albumin are located in hydrophobic cavities in subdomains IIA and ILIA, which exhibit similar chemistry. The structure explains numerous physical phenomena and should provide insight into future pharmacokinetic and genetically engineered therapeutic applications of serum albumin.
NASA分類LIFE SCIENCES (GENERAL)
レポートNO93A31628
権利Copyright


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