| タイトル | Beta-endorphin and arginine vasopressin following stressful sensory stimuli in man |
| 著者（英） | Kohl, Randall L. |
| 著者所属（英） | NASA Johnson Space Center; NASA Headquarters |
| 発行日 | 1992-11-01 |
| 言語 | eng |
| 内容記述 | This experimentation partially defines, for the first time, the response of beta-endorphin (ENDO) in man during tests designed to elicit nausea and motion sickness. These responses are similar to those associated with arginine vasopressin (AVP) and adreno-corticotropin (ACTH) to the extent that all hormones rise in response to motion sickness (p less than 0.003). Repeated exposure diminished motion-induced release of ENDO (p less than 0.005) and AVP (p less than 0.004) despite a three-fold increase in resistance to motion stimuli. Higher post-stress levels of AVP (p less than 0.04) and ACTH (p less than 0.02) were correlated with greater resistance to motion sickness. These data support the hypothesis that release of AVP is a significant link between stressful motion and motion-induced nausea and other autonomic system changes. Further, resistant individual apparently can tolerate higher peripheral levels of AVP before nausea results. Peripheral release of ENDO and ACTH may follow release of AVP; however, given the extensive and complex functional interactions that exist between AVP and the opiate systems, it is not yet possible to define a clear role for ENDO in the etiology of motion sickness. |
| NASA分類 | AEROSPACE MEDICINE |
| レポートNO | 93A16158 |
| 権利 | Copyright |
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