| タイトル | Photoaffinity labeling of regulatory subunits of protein kinase A in cardiac cell fractions of rats |
| 著者（英） | Popova, I.; Mednieks, M. I.; Grindeland, R. E. |
| 著者所属（英） | NASA Ames Research Center |
| 発行日 | 1992-08-01 |
| 言語 | eng |
| 内容記述 | Photoaffinity labeling in heart tissue of rats flown on Cosmos 2044 was used to measure the regulatory (R) subunits of adenosine monophosphate-dependent protein kinase. A significant decrease of RII subunits in the particulate cell fraction extract (S2; P less than 0.05 in all cases) was observed when extracts of tissue samples from vivarium controls were compared with those from flight animals. Photoaffinity labeling of the soluble fraction (S1) was observed to be unaffected by spaceflight or any of the simulation conditions. Proteins of the S2 fraction constitute a minor (less than 10 percent) component of the total, whereas the S1 fraction contained most of the cell proteins. Changes in a relatively minor aspect of adenosine monophosphate-mediated reactions are considered to be representative of a metabolic effect. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 92A51485 |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/324857 |
