| タイトル | Reduced lymphocyte activation in space - Role of cell-substratum interactions |
| 著者（英） | Cogoli, A.; Sonnenfeld, G.; Kiess, M.; Lee, J.; Gmuender, F. K. |
| 著者所属（英） | Eidgenoessische Technische Hochschule|Louisville Univ. |
| 発行日 | 1992-01-01 |
| 言語 | eng |
| 内容記述 | The effect of substratum adhesiveness on lymphocyte responsiveness was investigated by reducing and blocking cell adhesion with poly-HEMA in a simple on ground system. Cells grown on medium thick and thick poly-HEMA films were rounded in shape and displayed no signs of spreading. By contrast, on tissue culture plastic and very thin poly-HEMA films, they showed clear signs of spreading. The mitogenic response of lymphocytes grown on thick poly-HEMA films was reduced by up to 68 percent of the control (tissue culture plastic). Interferon gamma production was virtually nil when the cells were grown on the least adhesive substratum. These results show that activated lymphocytes need to anchor and spread prior to achieving an optimal proliferation response. It is concluded that decreased lymphocyte adhesion could contribute to the depressed in vitro lymphocyte responsiveness found in the microgravity conditions of space flight. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 92A20834 |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/330043 |
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