| タイトル | Space Flight Effects on Intracellular Ions in Sublingual Cells of Non-Human Primates |
| 著者（英） | Dotsenko, R.; Fung, P.; Wade, Charles E.; Arnaud, Sara B.; Silver, B.; Navidi, M. |
| 著者所属（英） | Institute of Biomedical Problems; NASA Ames Research Center; IntraCellular Diagnostics, Inc. |
| 発行日 | 1994-01-01 |
| 言語 | eng |
| 内容記述 | We have used a novel technique that quantifies minerals and electrolytes from smears of sublingual cells by x-ray microanalysis to monitor metabolic changes in bed rest subjects. Increases in intracellular calcium (Ca), phosphorus (P), and potassium (K) were characteristic of subjects whose exercise regimen was inadequate to maintain calcium metabolism. To test the effects of space flight on intracellular ions, we analyzed cells from 2-4 kg Rhesus monkeys before and after 2 weeks in space or chair restraint (CR). There were increases in sublingual cell Ca, P and K after space flight which paralleled the clinical estimates of metabolic status of the animals and exceeded the levels found during CR on R+11. Increases after 2 weeks CR were 26% in Ca, 6% in P and 29% in K. Species similarity ill responses of intracellular ions to inactivity imposed by bed rest, restraint or microgravity suggest that this innovative non-invasive technique would be a useful in-flight monitor of exercise countermeasures directed toward maintaining calcium balance. |
| NASA分類 | Life Sciences (General) |
| 権利 | No Copyright |
|
