| タイトル | Suppression of Antigen-Specific Lymphocyte Activation in Simulated Microgravity |
| 著者（英） | Risin, D.; Pellis, Neal R.; Cooper, D.; Brown, E.; Pride, M.; Dawson, David L. |
| 著者所属（英） | NASA Johnson Space Center |
| 発行日 | 1999-01-01 |
| 言語 | eng |
| 内容記述 | Various parameters of immune suppression are observed in astronauts during and after spaceflight, and in isolated immune cells in true and simulated microgravity. Specifically, polyclonal activation of T cells is severely suppressed in true and simulated microgravity. These recent findings with various polyclonal activators suggests a suppression of oligoclonal lymphocyte activation in microgravity. We utilized rotating wall vessel (RWV) bioreactors that simulate aspects of microgravity for cell cultures to analyze three models of antigen-specific activation. A mixed-lymphocyte reaction (MLR), as a model for a primary immune response; a tetanus toxoid (TT) response and a B. burgdorferi (Bb) response, as models of a secondary immune response, were all suppressed in the RWV bioreactor. Our findings confirm that the suppression of activation observed with polyclonal models also encompasses oligoclonal antigen-specific activation. |
| NASA分類 | Aerospace Medicine |
| 権利 | No Copyright |
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