| タイトル | Calcium and Bone Homeostasis During 4-6 Months Space Flight |
| 著者（英） | OBrien, K.; Smith, Scott M.; Wastney, M.; Abrams, S.; Paloski, W. H.; Lane, H.; Nillen, J.; Davis-Street, J.; Larina, I.; Morukov, B. |
| 著者所属（英） | Baylor Coll. of Medicine; NASA Johnson Space Center; Academy of Sciences (USSR); Johns Hopkins Univ.; Georgetown Univ. |
| 発行日 | 2000-01-01 |
| 言語 | eng |
| 内容記述 | Bone and calcium homeostasis are altered by weightlessness. We previously reported calcium studies on three subjects from the first joint US/Russian mission to Mir. We report here data on an additional three male subjects, whose stays on Mir were 4 (n= 1) and 6 (n=2) mos. Data were collected before, during, and after the missions. Inflight studies were conducted at 2-3 mos. Endocrine and biochemical indices were measured, along with 3-wk calcium tracer studies. Percent differences are reported compared to preflight. Ionized calcium was unchanged (2.8 +/-2.1 %) during flight. Calcium absorption was variable inflight, but was decreased after landing. Vitamin D stores were decreased 35 +/-24% inflight, similar to previous reports. Serum PTH was decreased 59 +/-9% during flight (greater than we previously reported), while 1,25(OH)(sub 2)-Vitamin D was decreased in 2 of 3 subjects. Markers of bone resorption (e.g., crosslinks) were increased in all subjects. Bone-specific alkaline phosphatase was decreased (n=1) or unchanged (n=2), while osteocalcin was decreased 34 +/-23%. Previously presented data showed that inflight bone loss is associated with increased resorption and unchanged/decreased formation. The data reported here support these earlier findings. These studies will help to extend our understanding of space flight-induced bone loss, and of bone loss associated with diseases such as osteoporosis or paralysis. |
| NASA分類 | Aerospace Medicine |
| 権利 | No Copyright |
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