| タイトル | Time Course and Variability of Polycythemic Response in Men at High Altitude |
| 著者（英） | McCullough, R. G.; Greenleaf, J. E.; Wolfel, E.; Reeves, J. T.; Seiland, M.; Dahms, T. E.; Grover, R. F. |
| 著者所属（英） | NASA Ames Research Center |
| 発行日 | 2000-01-01 |
| 言語 | eng |
| 内容記述 | Ten young men were exposed to 4,300 m (PB 460 Torr) for three weeks. Plasma volume (PV, Evans Blue dye). and blood volume (BV, carbon monoxide) measured simultaneously, and red cell volume (RCV) calculated from hematocrit, were determined twice at sea level and after 9-11 and 19-20 days at high altitude. After 19-20 days. half the subjects increased RCV +19.4 +/- 1.8% (p<0.001); the other 5 subjects had no significant change in RCV. All 10 subjects had a sustained decrease in PV (-16.2 +/- 1.9%, p<0.05) at altitude. Consequently, compared with sea level values, BV was unchanged (-3.1 +/- 1.8%) in the group with increased RCV, but BV decreased significantly (-12.2 +/- 1.4%, p<0.05) in the other group. Variability in RCV response was not explained by differences, in hypoxemic stimulus or the erythropoictin and reticulocyte responses. Since RCV reflects the balance between red cell. production and destruction, accelerated red cell destruction may have occurred in those individuals with no net change in RCV. |
| NASA分類 | Aerospace Medicine |
| 権利 | No Copyright |
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