| タイトル | Gravitational independence of single-breath washout tests in recumbent dogs |
| 著者（英） | Tomioka, Shinichi; Prisk, G. K.; Guy, Harold J. B.; Kubo, Susumu |
| 著者所属（英） | California Univ. |
| 発行日 | 1988-02-01 |
| 言語 | eng |
| 内容記述 | The effect of gravitational orientation in the mechanism of lung filling and emptying in dogs was examined by conducting simultaneously Ar-bolus and N2 single-breath washout tests (SBWTs) in 10 anesthetized dogs (prone and supine), with three of the dogs subjected to body rotation. Transpulmonary pressure was measured simultaneously, allowing identification of the lung volume above residual volume at which there was an inflection point in the pressure-volume curve. Combined resident gas and bolus SBWTs in recumbent dogs were found to be different from such tests in humans; in dogs, the regional distribution of ventilation was not primarily determined by gravity. The measurements did not make it possible to discern exact mechanisms of filling and emptying, but both processes appear to be related to lung, thorax, and mediastinum interactions and/or differences in regional mechanical properties of the lungs. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 88A27485 |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/372258 |
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