| タイトル | Effect of antiorthostatic suspension on interferon-alpha/beta production by the mouse (41939) |
| 著者（英） | Steffen, Joseph M.; Musacchia, X. J.; Mandel, Adrian D.; Rose, Andrea; Sonnenfeld, Gerald |
| 著者所属（英） | NASA Ames Research Center|Louisville Univ. |
| 発行日 | 1984-01-01 |
| 言語 | eng |
| 内容記述 | Mice were suspended in a model that simulates the weightlessness that occurs during prolonged space flight. After one and two weeks of suspension in an antiorthostatic (head-down tilt) position, the mice were challenged with polyriboinosinic-polyribocytidylic acid to induce interferon-alpha/beta. Interferon production was severely reduced in mice that had been suspended. When mice were allowed to recover in cages for a week following removal from suspension, they recovered their full interferon-production capacity. Mice suspended in an orthostatic (horizontal) position did not have their interferon production capabilities affected, which indicates that stress per se was not a major component in the effects of antiorthostatic suspension on interferon induction. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 88A20311 |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/373488 |
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