| タイトル | Glucocorticoid receptor-mediated induction of glutamine synthetase in skeletal muscle cells in vitro |
| 著者（英） | Konagaya, Masaaki; Thomas, John W.; Vitkovic, Ljubisa; Banner, Carl; Max, Stephen R. |
| 著者所属（英） | National Inst. of Neurological Diseases and Stroke|Maryland Univ. |
| 発行日 | 1987-01-01 |
| 言語 | eng |
| 内容記述 | The regulation by glucocorticoids of glutamine synthetase in L6 muscle cells in culture is studied. Glutamine synthetase activity was strikingly enhanced by dexamethasone. The dexamethasone-mediated induction of glutamine synthetase activity was blocked by RU38486, a glucocorticoid antagonist, indicating the involvement of intracellular glucocorticoid receptors in the induction process. RU38486 alone was without effect. Northern blot analysis revealed that dexamethasone-mediated enhancement of glutamine synthetase activity involves increased levels of glutamine synthetase mRNA. Glucocorticoids regulate the expression of glutamine synthetase mRNA in cultured muscle cells via interaction with intracellular receptors. Such regulation may be relevant to control of glutamine production by muscle. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 87A40945 |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/377541 |
|
