| タイトル | Hyperbaric hyperoxia reversibly inhibits erythrocyte phospholipid fatty acid turnover |
| 著者（英） | Dise, Craig A.; Goodman, David B. P.; Clark, James M.; Lambersten, Christian J. |
| 著者所属（英） | Pennsylvania Univ. |
| 発行日 | 1987-02-01 |
| 言語 | eng |
| 内容記述 | The effect of hyperbaric hyperoxia on the acylation of membrane phospholipid was studied by measuring the rates of activation of exogenous tritiated oleic acid to acyl thioester and of transesterification of the thioester into membrane phospholipids in intact human erythrocytes obtained 1 h after an exposure of the subjects to a hyperbaric oxygen atmosphere (3.5 h, 100 pct O2, 3 ATA). Exposure to pure oxygen was found to inhibit both the acylation and transesterification reactions by more than 30 percent, with partial recovery detected 24 h later. On the other hand, no rate changes were observed when isolated membranes from the same batches of cells were used in similar experiments. It is suggested that the decrease in the incorporation of tritiated oleic acid after hyperbaric hyperoxia may reflect an early event in the pathogenesis of oxygen-induced cellular injury and that it may be a useful index for the assessment of the tolerance of tissues to hyperoxia. |
| NASA分類 | AEROSPACE MEDICINE |
| レポートNO | 87A33941 |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/378534 |
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