| タイトル | Skeletal response to simulated weightlessness - A comparison of suspension techniques |
| 著者（英） | Wronski, T. J.; Morey-Holton, E. R. |
| 著者所属（英） | NASA Ames Research Center|Florida Univ. |
| 発行日 | 1987-01-01 |
| 言語 | eng |
| 内容記述 | Comparisons are made of the skeletal response of rats subjected to simulated weightlessness by back or tail suspension. In comparison to pair-fed control rats, back-suspended rats failed to gain weight whereas tail-suspended rats exhibited normal weight gain. Quantitative bone histomorphometry revealed marked skeletal abnormalities in the proximal tibial metaphysis of back-suspended rats. Loss of trabecular bone mass in these animals was due to a combination of depressed longitudinal bone growth, decreased bone formation, and increased bone resorption. In contrast, the proximal tibia of tail-suspended rats was relatively normal by these histologic criteria. However, a significant reduction trabecular bone volume occurred during 2 weeks of tail suspension, possibly due to a transient inhibition of bone formation. The findings indicate that tail suspension may be a more appropriate model for evaluating the effects of simulated weightlessness on skeletal homeostasis. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 87A28847 |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/379253 |
|
