| タイトル | Role of carbonic anhydrase in bone resorption induced by 1,25 dihydroxyvitamin D3 in vitro |
| 著者（英） | Hall, G. E.; Kenny, A. D. |
| 著者所属（英） | Texas Technological Univ. |
| 発行日 | 1985-01-01 |
| 言語 | eng |
| 内容記述 | The calvaria of 5-to-6-day-old mice treated with 1 x 10 to the -8th M of 1,25(OH)2D3 in vitro for 48 hours are examined in order to study the function of carbonic anhydrase in bone resorption. Calcium concentrations in the culture were measured to assess bone resorption. It is observed that 1,25(OH)2D3 effectively stimulates bone resorption in vitro and the resorption is dose-dependent. The effects of azetazolamide on 1,25(OH)2D3-induced bone resorption are investigated. The data reveal that 1,25(OH)2D3-induced calcium release is associated with an increase in the carbonic anhydrase activity of bone, and bone alkaline phosphatase activity is decreased and acid phosphatase activity is increased in response to 1,25(OH)2D3. A two-fold mechanism for 1,25(OH)2D3-induced bone resorption is proposed; the first mechanism is an indirect activation of osteoclasts and the second involves an interaction between hormone and osteoclast precursors. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 86A43449 |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/383692 |
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