| タイトル | Morphological and biochemical changes in soleus and extensor digitorum longus muscles of rats orbited in Spacelab 3 |
| 著者（英） | Satyanarayana, T.; Riley, D. A.; Sedlak, F. R.; Bain, J. L. W.; Elis, S.; Slocum, T. |
| 著者所属（英） | Medical Coll. of Wisconsin|NASA Ames Research Center |
| 発行日 | 1985-12-01 |
| 言語 | eng |
| 内容記述 | Muscle atrophy in rats exposed to hypogravity for seven days aboard Spacelab 3 is examined. Hindlimb muscles were harvested 12-16 days postflight, and prepared for enzyme studies and electron microscopy. Simple cell shrinkage was found, with a mean fiber area decrease of 35.8 percent for soleus and 24.9 percent for extensor digitorum longus (EDL) flight muscle fibers, as compared with control muscle fibers. EDL and soleus muscles showed increases in alkaline myofibrillar ATPase, alpha glycerophosphate dehydrogenase, and glycogen, and a decrease in NADH dehydrogenase staining. The 26 percent increase in calcium activated protease suggests that the focal degradation of myofibrils is the key process of myofibril breakdown. The presence in the flight soleus muscles of one percent necrotic fibers is unexplained. The observed shift towards histochemical fast-muscle type properties is consistent with previous findings. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 86A30464 |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/385612 |
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