| タイトル | Hyper-G stress-induced hyperglycemia in rats mediated by glucoregulatory hormones |
| 著者（英） | Daligcon, B. C.; Oyama, J. |
| 著者所属（英） | NASA Ames Research Center |
| 発行日 | 1985-01-01 |
| 言語 | eng |
| 内容記述 | The present investigation is concerned with possible relations of the hyperglycemic response of rats exposed to hyper-G stress to (1) alterations in blood levels of the glucoregulatory hormones and gluconeogenic substrates, and (2) changes in insulin response on muscle glucose uptake. Male Sprague-Dawley rats weighing 250-300 g were used in the study. The results of the experiments indicate that the initial rapid rise in blood glucose of rats exposed to hyper-G stress is mediated by increases in circulating catecholamines and glucagon, both potent stimulators of hepatic gluconeogenesis. Lactate, derived from epinephrine stimulation of muscle glycogenolysis, appears to be a major precursor for the initial rise in blood glucose. The inhibition of the insulin-stimulated glucose uptake by muscle tissues may be a factor in the observed sustained hyperglycemia. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 85A27666 |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/392423 |
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