| タイトル | Physiological changes in fast and slow muscle with simulated weightlessness |
| 著者（英） | Misulis, K. E.; Dettbarn, W. D. |
| 著者所属（英） | Vanderbilt Univ. |
| 発行日 | 1984-02-01 |
| 言語 | eng |
| 内容記述 | A rat hindlimb suspension model of simulated weightlessness was used to examine the physiological characteristics of skeletal muscle. The physiological sequelae of hindlimb suspension were compared to those of spinal cord section, denervation by sciatic nerve crush, and control. Muscle examined were the predominantly slow (Type 1) soleus (SOL) and the predominantly fast (Type 2) extensor digitorum longus (EDL). Two procedures which alter motor unit activity, hindlimb suspension and spinal cord section, produce changes in characteristics of skeletal muscles that are dependent upon fiber type. The SOL develops characteristics more representative of a fast muscle, including smaller Type 1 fiber proportion and higher AChE activity. The EDL, which is already predominantly fast, loses most of its few Type 1 fibers, thus also becoming faster. These data are in agreement with the studies in which rats experienced actual weightlessness. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 84N18850 |
| 権利 | No Copyright |
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