| タイトル | Quantitative histochemistry of rat lumbar vertebrae following spaceflight |
| 著者（英） | Eurell, J. A.; Kazarian, L. E. |
| 著者所属（英） | Florida Univ.|Aerospace Medical Research Labs. |
| 発行日 | 1983-03-01 |
| 言語 | eng |
| 内容記述 | The histochemical effects of the return to gravity immediately and 6 and 29 days following spaceflight on the bone of rat vertebral bodies were investigated. No significant change in the calcium salt content of the vertebrae was found immediately postflight, although 6 days later it was significantly decreased. The calcium content was found to have returned to normal by 29 days postflight. While postflight collagen content was not significantly altered, keratosulfate was found to be significantly higher in trabecular bone of rats immediately postflight and 6 days postflight. In addition, chondroitin sulfate was found to be increased in vertebral bone on days 6 and 29 postflight. These findings indicate that bone turnover slows in vertebrae during spaceflight allowing bone aging, which support the contention that a form of osteolysis begins immediately upon return to gravity to remove components of old bone at which time mineral levels decrease and levels of chondroitin and keratkosulfates shift. It was found that the osteolysis phase was quickly followed by new bone replacement which was completed before 29 days postspaceflight. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 83A44864 |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/402628 |
|
