| タイトル | Role of metabolic rate and DNA-repair in Drosophila aging Implications for the mitochondrial mutation theory of aging |
| 著者（英） | Miquel, J.; Binnard, R.; Fleming, J. E. |
| 著者所属（英） | NASA Ames Research Center|Linus Pauling Inst. for Science and Medicine |
| 発行日 | 1983-01-01 |
| 言語 | eng |
| 内容記述 | The notion that injury to mitochondrial DNA is a cause of intrinsic aging was tested by correlating the different respiration rates of several wild strains of Drosophila melanogaster with the life-spans. Respiration rate and aging in a mutant of D. melanogaster deficient in postreplication repair were also investigated. In agreement with the rate of living theory, there was an inverse relation between oxygen consumption and median life-span in flies having normal DNA repair. The mutant showed an abnormally low life-span as compared to the controls and also exhibited significant deficiency in mating fitness and a depressed metabolic rate. Therefore, the short life-span of the mutant may be due to the congenital condition rather than to accelerated aging. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 83A41861 |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/403034 |
