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タイトルAntimotion-sickness efficacy of scopolamine 12 and 72 hours after transdermal administration
著者(英)Wood, C. D.; Cramer, D. B.; Graybiel, A.
著者所属(英)Louisiana State Univ.; Naval Aerospace Medical Research Lab.; NASA Headquarters
発行日1982-08-01
言語eng
内容記述The antimotion sickness remedy, transdermal therapeutic system-scopolamine, administered in this experiment was scheduled to deliver 1.0 mg of scopolamine over a period of 3 d, and this paper compares its efficacy 12 and 72 h after administration. In a double-blind study, six male college students were individually exposed to a standardized provocative test in a slow rotation room after six apparently identical treatments comprising four placebos and two medications. Efficacy was categorized as beneficial, inconsequential, or detrimental. None of the responses was detrimental. Following the first administration of the therapeutic system, there were four beneficial responses after 12 h but none was beneficial after 72 h. Following the second treatment regimen, there were four beneficial responses after 12 h and three beneficial responses after 72 h. Great individual differences were demonstrated, two subjects accounting for six beneficial responses and two accounting for only one beneficial response. The difference in efficacy after 12 and 72 h has practical and theoretical significance.
NASA分類AEROSPACE MEDICINE
レポートNO82A40437
権利Copyright


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