| タイトル | Formation of peptides from amino acids by single or multiple additions of ATP to suspensions of nucleoproteinoid microparticles |
| 著者（英） | Fox, S. W.; Nakashima, T. |
| 著者所属（英） | Miami Univ. |
| 発行日 | 1981-01-01 |
| 言語 | eng |
| 内容記述 | The synthesis of peptides from individual amino acids or pairs of amino acids and ATP in the presence of catalysis by nucleoproteinoid microparticles is investigated. Experiments were performed with suspensions formed from the condensation of lysine-rich and acidic proteinoids with polyadenylic acid, to which were added glycine, phenylalanine, proline, lysine or glycine-phenylalanine mixtures, and ATP either at once or serially. Peptide yields are found to be greatest for equal amounts of acidic and basic proteinoids. The addition of imidazole is found to alter the preference of glycine-phenylalanine mixtures to form mixed heteropeptides rather than homopeptides. A rapid ATP decay in the peptide synthesis reaction is observed, and a greater yield is obtained for repeated small additions than for a single addition of ATP. The experimental system has properties similar to modern cells, and represents an organizational unit ready for the evolution of associated biochemical pathways. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 82A26597 |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/411408 |
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